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(1) A 47 years old man presented with a space occupying lesion in liver. Liver biopsy showed it to be hepatocellular carcinoma. As part of initial workup for surgical resection an angiogram was performed. What should be the angiogram findings in this malignant neoplasm:

(2) Which of the following cell type is most effective in host defense against tumors:

(3) A breast tumor was sent to histopathology lab after lumpectomy. The tumor was encapsulated with a solid, smooth and regular cut surface. Microscopy revealed a neoplasm resembling the normal lobular architecture of breast. In which of the following categories this neoplasm will fall:

(4) A 37 years old woman presented with breast lump. The biopsy showed it to be ductas carcinoma. Which route of spread this tumor is most likely to follow:

(5) A 33 years old man presented with progressive loss of body fat and lean body mass, accompanied by profound weakness,anorexia and anemia. Investigations revealed him to have a malignant bone tumor. Which of the following mediator produced by the tumor is responsible for his clinical symptoms:

(6) A 45 years old man presented with central obesity,moon face,thin skin and abdominal striae. He was clinically diagnosed with cushing syndrome. His ACTH levels were high. But neither the pituitary gland nor the adrenal gland reveal any lesion. A lungs hilar mass was detected on X-ray chest. Doctor suspected small cell carcinoma. The unrelated symptom complex in the patient with cancer is refferred to as:

(7) The most common paraneoplastic syndrome is:

(8) Which one of the following neoplasms is locally invasive but seldom spread by metastasis:

(9) Metastasis refers to the spread of neoplastic cells from one part of the body to another. Which one of the following is true for metastasic neoplasms:

(10) Which of the following tumor marker is of diagnostic value in colorectal carcinoma:

(11) Which of the following statements regarding Familial Rb gene is correct:

(12) Workers heavily exposed to aniline dye are at risk of developing which of the following cancers:

(13) Which of the following chemical carcinogens can cause skin cancers when painted on skin or can induce sarcomas when injected subcutaneously:

(14) Which of the following are most likely radiation induced cancers:

(15) A child has pigeon breast deformity along with lumbar lordosis and bowing of the legs. What is the most likely diagnosis:

(16) Which of the following is the most common primary renal tumor of childhood:

(17) A cancer initiator causes an initiated cell. To form a malignant neoplasm a promoter is required. Which action of promoter is necessary for tumor formation:

(18) After exposure to a radiation leak, the exposed population is at an increased risk of developing cancer.The action of which of the following genes is paramount in reducing the risk of canceer development in this case:

(19) During metastasis the tumor cells in blood bnid with which of the following blood cells as they travel in circulation and avoid host defense mechanism:

(20) Acording to latest tumor nomenclature, which of the following is a malignant tumor:

(21) A 42 years old man is concerned about a darkly pigmented mole on the back of his hand. The lesion has enlarged and bled during the past month. On physical examination there is a slighthly raised darkly pigmented 12 cm lesion on the dorsum of the right hand. The lesion is completely excised. Microscopically a maligant melanoma is present. Which of the following factors present the greater risk for the development of this neoplasm:

(22) A five years old child has difficulty with vision in the right eye. On physical examination, there is a mass in the posterior chamber that nearly fills the globe. The child undergoes enucleation of the right eye. Molecular analysis of the neoplastic cells indicates absense of both copies of a tumor suppressor gene that controls the transition from the G1 to the S phase of the cell cycle. Which of the following gene is most likely to have the mechanism of action that produced this neoplasm:

(23) A 32 years old woman has experienced dull pelvic pain for the past two months .Physical examination shows a right adenxal mass . An abdominal ultrasound shows a 7.5 cm cystic ovarian mass. The mass is surgically excised. On grass examination ,the mass is cystic and filled with hair,teeth and sebum. Microscopically ,squamous epithelium,tall columnar glandular epithelium,cartilage are present. Which of the following is the most likely diagnosis:

(24) A 45 years old woman sees her physician because she feels lumps in the right axilla. The physician notes right axillary lymphadenopathy on physical examination. The nodes are painless but firm. Which of the following is the most likely diagnosis:

(25) A 58 years old smoker presents to the emergency department with shortness of breath and hameoptysis. Portable chest radiography demonstrate lung mass. He has hypercalemia. The metabolic abnormality described here is likely due to the elaboration of which substance:

(26) In hemangioma, which tissue component shows proliferation histologically:

(27) A 15 year old boy has roughened corneal surface caused by xeropthalmia. Keratomalacia results in corneal scarring. This ocular damage most likely could have been prevented by treating a dietry deficiency of which of the following nutrient:

(28) The tumor marker raised in heppatocellular carcinoma is:

(29) The most likely casuative agent for bladder cancer amongst those working in the rubber industry is :

(30) A 62 years old man has complained of pain on urination for the last week. He is afebrile. On eystoscopy a slightly erythematous 1 cm diameter is seen on the bladder mucosa.This area is biopsed and on microscopic examination shows cells with marked hyperchromatism and increased nuclear/cytoplasmic ratio involving the full thickness of the epithelium. However these changes are confined to the epithelium above the basement membrane. Which of the following terms best describes these biopsy findings:

(31) Antigens which are expressed both on tumor as well as normal cell are called as:

(32) A 55 years old man visits the physician because of hemoptysis and worsening cough. On physical examination wheezes are ausculated over the right lung posteriorly. A chest radiograph shows a 6 cm mass on the right. A fine needle aspiration biopsy yields cells consistent with non small cell bronchogenic carcinoma. Molcular analysis of the neoplatic cells shows a p53 gene mutation. Which of the following meachnism has most likely produced the neoplastic transformation:

(33) Malignant tumour of mesenchymal origin:

(34) Tumour with more than one gram layer is:

(35) Mass of disorganized but mature specialized cells indigenous to particular site is:

(36) Ectopic rest of normal tissue is:

(37) Normal nuclear cytoplasmic ratio is:

(38) A hyperchromatic large nucleus is a feature of:

(39) The cells that control haematogenous spread of tumour are:

(40) The most potent carcinogen is:

(41) The growth factor with oncogenic potential is:

(42) The only leukaemia which is virus induced is:

(43) Which virus is carcinogenic for liver: