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(1) A 75 year old woman Mrs Mashaal has stable angina and stenosis of a branch of coronary artery that perfuses a large segment of the myocardium. She is scheduled to undergo Percutaneous Transluminal Coronary Angioplasty (PTCA) to revascularize the myocardium. Which one of the following agents would most likely be given to prevent platelet aggregation during PTCA and acts by binding to glycoprotein receptors:

(2) Cutaneous necrosis and haemorrhagic infarction of remote peripheral adipose tissues due to reduced protein C &S activity occurs during the first weeks of therapy with:

(3) Which of the following is unlikely to be a Low Molecular Wt Heparin:

(4) Which of the following is unlikely to be a direct thrombin inhibitor:

(5) Minralocorticoid deficiency and hyperkalemia can be a complication with the use of:

(6) A patient receiving an anti-hyperlipidemic drug experiences cutaneous vasodilation after each dose at onset. Which anti-hyperlipidemic drug is he receiving:

(7) A patient taking an antihyperlipedemic drug experiences constipation and bloating as common adverse effects. Which hypolipidemic drug is he taking:

(8) Which one of the following anti-hyperlipidemic drugs is most likely to cause rhabdomyolysis and myoglobinurea:

(9) Which one of the following anti-hyperlipidemic drugs is most likely to reduce serum levels of digoxin, Warfarin,Tetracyclines,and thiazide diuretics:

(10) The direct-acting activator of plasminogen-plasmin system is:

(11) Patients with normal platelet counts and normal bleeding time may still bleed severely as a result of aspirin ingestion prior to a dental or surgical procedure. The aspirin interference with normal platelet function may last as long as:

(12) A 54 year old male with DVT is started on a bolus of heparin. Thirty minutes later, he is bleeding profusely from the intravenous site. Heparin is stopped but the bleeding continues. Protamine is given which acts by:

(13) A 60 year old male comes to the emergency department with severe crushing chest pain of I hour duration. ECG and blood chemistry are consistent with a diagnosis of MI. Streptokinase is administered whose mechanism of action is to:

(14) A 41 year old man is being treated for leukemia. He develops septicemia and suffers from widespread ecchymoses and profuse bleeding. Lab results confirm Disseminated intravascular coagulation (DIC). In addition to giving fresh frozen plasma and antibiotics, which one of the following agents will also be useful:

(15) A 63 year old Mr.Pervez, has a history of atrial fibrillation. To reduce his risk of stroke, his physician has given him an anti-coagulant medication. This medication however may cause spontaneous hemorrhage. To monitor the medication, the patient comes frequently to the laboratory for prothrombin levels. Which medication is the patient taking:

(16) A 53 year old obese female is brought to the emergency ward by her concerned husband 1 hour after complaining of constant abdominal pain, nausea and shortness of breath. ECG and cardiac enzymes confirm the diagnosis of MI. Which drug should be administered to this pt:

(17) A patient receiving unfractionated heparin has recently developed thrombocytopenia. Which of following should he receive now for anticoagulation:

(18) Agents primarily used to treat hypercholesterolemia which work by inhibiting the HMG-CoA reductase enzyme include:

(19) A patient is being treated with Warfarin subsequent to suffering from a pulmonary embolus. Phenobarbital is later prescribed for nighttime sedation. Which alternation in Warfarin dosage is indicated:

(20) A patient is given an anti-hyperlipidemic agent that reduces circulating cholesterol levels by binding to bile acids in the gut. Which one of the following is it:

(21) Which of the following drugs does not cross the placenta and has no significant concentration in milk in the lactating female:

(22) In a patient with a high risk for coronary artery disease (LDL cholesterol 200 mg/dl, normal triglycerides), the best lipid-lowering drug would be:

(23) 45-year-old woman who is being treated for hypertension and hypercholestremia develops diffuse muscle pain and weakness. Serum Creatinine kinase activity is increased. Which of the following drugs is most likely to have caused this clinical picture:

(24) The antithrombotic drug which acts by inhibiting cyclooxygenase enzymes and is commonly used as antiplatelet therapy is:

(25) A patient is given an anti-hyperlipidemic agent that reduces circulating cholesterol levels by binding to cholesterol in the gut. Which one of the following is it:

(46) Clopidogrel, an ADP receptor antagonist is now preferred over ticlopidine for antiplatelet action because:

(27) Mr. Zahid 52 years old, driver by profession, who was heavy smoker for more than 30 years & was hypercholestrolemic, suffered from acute heart attack. He was getting fibrinolytic therapy for myocardial infarction. After being stabilized he developed symptoms of over dosage. Which of the following can control the symptoms of over dosage of thrombolytic therapy:

(28) Which of the following drugs binds to FKBP 12 forming a complex that leads to inhibition of calcineurin:

(29) As a gastroenterologist, a patient of atrial fibrillation taking warfarin comes to you with symptoms of dyspepsia. You prescribe an anti-peptic ulcer drug. After a few hours you receive a call from his cardiologist that the patient has been admitted for warfarin toxicity. Which anti-peptic ulcer drug did you negligibly prescribe to him:

(30) A patient has severe diabetic gastroparesis and gastroesophageal reflux, which requires relief. Which drug would be most suitable for him:

(31) A patient who has liver cirrhosis due to chronic hepatitis C viral infection, presents with hepatic encephalopathy. Which one of the following drugs would be most suitable for the relief of signs and symptoms of this condition:

(32) A 35 year old female treated for bronchial asthma develops skeletal muscle tremors that are drug-induced. Which one of the following drugs was he administered:

(33) Recurrent strokes can be prevented with long term therapy of which of the following drug:

(34) Cutaneous necrosis due to reduced protein C activity occurs during the first week of therapy with which of the following drugs:

(35) Minralocorticoid deficiency and hyperkalemia can be a complication with the use of which of the following anticoagulants:

(36) Which one of following increase cAMP in platelets and inhibit their aggregation by altering levels of TxA2 or prostacycline:

(37) Streptokinase is given to a patient for fibrinolytic activity. Most important complication of streptokinase therapy is:

(38) A diabetic hypertensive lady has xanthomas. Her lab reports shows a cholesterol level of 500 mg/dl. Which is the most potent drug for treating hypercholesterolemia:

(39) A 65 years old male is prescribed HMG Co-A reductase inhibitor. What is a rare but characteristic adverse effect he is likely to develop:

(40) Plasma expenders are not used to increase the plasma volume in which of the following conditions:

(41) A patient is on antiplatelet therapy for last 6 months. Without taking history which of these conditions is least likely for this patient to have: